Sedation with non sedating antihistamines

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Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.

Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.

Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.

Sustained-release: 8 or 12 mg po every 8 to 12 hours. Supplied: Extended Release Cap: 6 mg, 8 mg, 12 mg Liquid/syrup: 2 mg/5 ml Tablet: 2 mg, 4 mg.

Chewable: 2 mg EExtended Release tab: 8 mg, 12 mg, 16 mg Tavist 12 Hour Allergy Tablets: Clemastine fumarate, USP 1.34 mg (equivalent to 1 mg clemastine).

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